|
KMID : 0854720070270020140
|
|
Korean Journal of Asthma, Allergy and Clinical Immunology
2007 Volume.27 No. 2 p.140 ~ p.142
|
|
|
Lamotrigine-Induced Hypersensitivity Syndrome Accompanied with Aseptic Meningitis
|
|
Lee So-Hee
Yang Min-Suk
Kim Tae-Wan
Kwon Jae-Woo
Lee Sang-Min
Kwon Hyouk-Soo
Park Heung-Woo
Chang Yoon-Seok
Kim Sun-Sin
Cho Sang-Heon
Min Kyung-Up
Kim You-Young
|
|
|
Abstract
|
|
|
|
Drug-induced aseptic meningitis (DIAM) is a rare manifestation of drug-induced hypersensitivity syndrome. Lamotrigine is a non-aromatic anticonvulsant drug with antidepressant activity and widely used nowadays. So far, several cases of lamotrigine-induced hypersensitivity syndrome have been reported. However, there has been only one case report of lamotrigine-induced DIAM worldwide. A 33-yearold woman with an 8-year history of bipolar disorder was hospitalized, complaining of fever, a generalized maculopapular rash, leucocytopenia, hepatic dysfunction, and lymphadenopathy which developed 10 days after initiation of lamotrigine treatment. In addition, she presented meningeal irritation signs, and cerebrospinal fluid examination showed pleocytosis, an increased protein concentration, and a normal glucose level. However, no evidence of an infectious condition was found. Based on clinical and laboratory findings, we diagnosed her as having lamotrigine-induced hypersensitivity syndrome with DIAM and administered methylprednisolone systemically. Her clinical symptoms quickly improved and abnormal laboratory findings were normalized. To the best of our knowledge, this is the first case of lamotrigine-induced DIAM in Korea. (Korean J Asthma Allergy Clin Immunol 2007;27:140-142)
|
|
|
KEYWORD
|
|
|
Drug-induced aseptic meningitis, Hypersensitivity syndrome, Lamotrigine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|